Changes of Bid Gene Expression in Neonttal Rats with Hypoxic-Ischemic Brain Dama ge
- VernacularTitle:Bid基因在新生大鼠缺氧缺血性脑损伤中的动态变化
- Author:
Ai-zhen, WANG
;
Shu-ting, LI
;
Xi-rong, GUO
- Publication Type:Journal Article
- Keywords:
cerebral hypoxia;
cerebral ischemia;
Bid gene;
apoptosis
- From:Journal of Applied Clinical Pediatrics
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes and significance of Bid gene expression in hypoxic-ischemic brain damage (HIBD) in neonatal rats.Methods The animal models of HIBD were made. Total RNA from ipsilateral cerebral hemisph ere was extracted.RT-PCR was used to evaluate the levels of Bid gene expression at different time points after hypoxic-ischemic. Results The levels of Bid mRNA were higher in HIBD rats than those in normal rats.The ex pression of Bid mRNA in ipsilateral hemiphere following cerebral hypoxic-ischem ic began to increase at 6 h, increased to the highest level at 24 h, and then gr adually returned.Conclusion The upregulation of Bid mRNA can play a role in the induction of apoptosis fol lowing cerebral hypoxic-ischemic. J Appl Clin Pediatr,2005,20(2):121-122
