Study on Resistance of Brains at Different Developmental Stages Following Penty lenetetrazol-Induced Recurrent Seizures in Rats
- VernacularTitle:不同成熟期大鼠对戊四氮反复致性损伤的耐受性研究
- Author:
dan, SUN
;
ya-ling, HUANG
;
ya-li, LIU
- Publication Type:Journal Article
- Keywords:
hippocampus;
seizure;
rats;
pentylenetetrazol
- From:Journal of Applied Clinical Pediatrics
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine if there is an early developmental resistance to seizure-induced hi ppocampal damage. Methods Five daily pentylenetetrazol-indu ced convulsions in immature rats beginning at postnatal day P10,P60 groups.In b oth groups, the latency of seizure, the latency of Ⅳ/Ⅴ grade, the lasting time of seizure and mortality of rats after seizure were used to measure sensitivity of seizure or the resistance to brain damage. Conventional histopathological me thod was utilized to observe morpbological changes and cell counting of dentate granule cells, CA 3,CA 1 and hilar neurnns. Timm histochemical technique was a dopted to study mossy fiber sprou- ting.Results 1.In the both groups(P10,P60),there were significant differences in the latency of seizure (1.07?0.55 vs 8.27?1.48 P
