Expression of Survivin, Anti Apoptosis Gene in Leukemia and Correlation between Expression of Survivin,Fas and Caspase
- VernacularTitle:Survivin在白血病中表达及其与Caspase、Fas相关性研究
- Author:
yan-feng, XIAO
;
ya, LIU
;
wei, TIAN
;
li-fen, REN
- Publication Type:Journal Article
- Keywords:
leukemia;
Survivin;
apoptosis;
gene expression;
Western blot analysis;
Fas;
Caspase-3
- From:Journal of Applied Clinical Pediatrics
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relation ship between expression of survivin gene in leukemia cells and its clinical effects, and to study the mechanism of survivin resist-apoptosis function in leukemia.Methods Survivin expression was detected by Western blots analysis and expressions of Fas and Caspase were examined by immunohistochemistry in 18 leukemia patients.Results Thirteen cases in peripheral blood mononuclear cell survivin positive expression was detected in 18 leukemia patients(72.2%), but no survivin expression in 10 normal persons. There were significant difference of survivin expression in ALL/ANLL patients groups and different WBC groups(P
