Analysis of Peripheral T-Lymphocytic Cell Phenotypes in Children with Aplastic Anemia
- VernacularTitle:再生障碍性贫血患儿外周血淋巴细胞表型分析
- Author:
mei-juan, WANG
;
hai-long, HE
;
jian-yi, LIAO
- Publication Type:Journal Article
- Keywords:
aplastic anemia;
immune;
T cell subpopulation phenotypes
- From:Journal of Applied Clinical Pediatrics
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the phenotypes and expression of activated T-cell membrane molecules on lymphocytes in the peripheral blood(PB) of children with aplastic anemia (AA) and find out its clinical significance.Methods The lymphocytes from PB of the 115 AA patients were analyzed by flow cytometry and compared with normal group.Results The expression of CD8+ increased and the expression of CD4+ decreased. The ratio of CD4/CD8 cells decreased ,and was more significant in the patients with serious AA(SAA). The expression of HLA-DR and ??T-cell also increased, and was more significant in SAA patients. The expression of CD3+ was not significantly changed.Conclusions There is significant immune abnormal in AA patients and more important in SAA patients. The immunosuppressant is useful in clinical treatment.
