Clinical Analysis of Virus-Associated Hemophagocytic Syndrome in Children
- VernacularTitle:病毒相关性噬血细胞综合征的诊断与治疗
- Author:
yuan, LI
;
hai-xia, ZHOU
;
ju-xiang, WANG
;
jiang-chao, QIAN
- Publication Type:Journal Article
- Keywords:
hemophagocytic syndrome;
Epstein-Barr virus;
diagnosis
- From:Journal of Applied Clinical Pediatrics
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To increase the awareness of virus-associated hemophagocytic syndrome.Methods Sixteen cases of virus-associated hemophagocytic syndrome were retrospectively analyzed.Results All presented with persistent high fever,cytopenia,hepato-splenomegaly,hepatic dysfunction,hypertriglyceridemia,hyperferritinemia,coagulopathy,hypofibrinogenemia,cytokine storm and a low natural killer cell activity.All patients had lymphohistiocytic accumulation in bone marrow.Treatment with high-dose gamma-globulin and high-dose methylprednisolone.Clinical symptoms and laboratory improved,and five patients died.Conclusion Aggressive early diagnosis and treatment are critical to improve survival.
