Pathogenic Role of Glutamic Acid in Tourette's Syndrome
- VernacularTitle:谷氨酸对多发性抽动症发病的影响
- Author:
jian, LIU
;
zhan-yang, HUO
- Publication Type:Journal Article
- Keywords:
glutamic acid;
children;
Tourette's syndrome;
stereotyped locomotion;
excitatory ammo acid
- From:Journal of Applied Clinical Pediatrics
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of glutamic acid (monosodium glutamate,MSG) on Tourette's syndrome (TS). Methods These rats were divided into 2 groups: one group with acute intracerebroventricularly injection (ICV) of MSG or artificial cerebrospinal fluid (CSF), and another group with chronic administration of MSG in a dose of 40 mg/kg in drinking water everyday. Observers who were blind to the two- part subjects assessed the scores of TS- like stereotyped locomotion. Results 1. These groups of 100 ?g or 200 ?g glutamic acid may induce significant TS - like stereotyped locomotion ( P
