Relationship between Renal Nitric Oxide and Glomerular Hyper filtration in Experimental Diabetic Rats
- VernacularTitle:实验性糖尿病大鼠肾组织一氧化氮与肾小球高滤过的关系
- Author:
ming-hua, LIU
;
shu-zhen, SUN
;
qian, LI
;
yi, WANG
- Publication Type:Journal Article
- Keywords:
nitric oxide;
nitric oxide synthase;
diabetic nephropathies;
glomerular filtration rate;
rats;
inbred strains
- From:Journal of Applied Clinical Pediatrics
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mobile changes of nitric oxide(NO) and the relationship between nitric oxide and glomerular hyperfiltration in experimental diabetic rats.Methods Experimental diabetes mellitus(DM) was induced in rats with streptozotocin(STZ).The levels of NO and NOS in renal tissue homogenate were assayed after establishment of diabetesat the 4 th,8 th,12 th week.At the same time, renal morphology in diabetic rats was examined by light microscope and image of computer.Results The contents of NO and NOS in renal homegenates were evidently increased at 4 th week,and decreased gradually from 8 th week(P
