Correlation between Angiotensin Converting Enzyme Gene Polymorphism and Kawasaki Disease
- VernacularTitle:血管紧张素转换酶基因多态性与川崎病的相关性
- Author:
dong-hai, LIU
;
xiu-ying, WANG
;
yi, XU
- Publication Type:Journal Article
- Keywords:
kawasaki disease;
angiotensin converting enzyme;
gene polymorphism
- From:Journal of Applied Clinical Pediatrics
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between angiotensin converting enzyme(ACE) gene polymorphism and kawasaki disease(KD).Methods A 287 bp Alu fragment in intron 16 of the ACE gene was used as insertion(I)/deletion(D) polymorphism marker. The ACE genotype of 28 children (10 children complicated coronary dilataltion) with KD and 35 healthy controls were detected by polymerase chain reaction (PCR), and ACE concentration in blood serum was measured by ultraviolet-spectrophotometer assay.Results 1.The ACE concentration was significantly higher in KD group than that in healthy control group(P
