Relationship of Placental Leptin and Leptin Receptor mRNA Expression and Intrauterine Growth Retardation
- VernacularTitle:胎盘组织中瘦素及瘦素受体表达与胎儿宫内发育迟缓
- Author:
luan-ying, TIAN
;
shi, CHEN
;
wu-hong, GAO
;
jing, ZHANG
- Publication Type:Journal Article
- Keywords:
leptin receptor;
newborns;
growth;
retardation
- From:Journal of Applied Clinical Pediatrics
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between the levels of leptin and leptin receptor in placental and intrauterine growth retardation.Methods Eighty seven newborns were studied .Auxological data(birth weight, length and biceps, triceps, subscapular and iliac skinfold thickness) were obtained and recorded.According to birth weight ,the subjects were divided into :the small for gestational age(SGA)group and the appropriate for gestational age (AGA) group.The levels of leptin and leptin receptor mRNA in 87 placental tissue were assayed by reverse transcription-polymerase chain reaction(RT-PCR).Results 1. The level of leptin receptor mRNA in placental was 0.894?0.291, which was positively related to the birth weight and body fat content (r=0.651,0.581,both P
