Changes of tumor necrosis factor-? levels in serum and cerebrospinal fluid of childhood acute leukemia before and after treatment
- VernacularTitle:急性白血病治疗前后血液和脑脊液肿瘤坏死因子-?水平变化
- Author:
ya-ping, YU
;
ji-hong, YANG
;
yuan-feng, FU
;
ping, SHI
;
hai-ning, LIU
;
yong-ping, ZHAI
;
guo-hong, WANG
- Publication Type:Journal Article
- Keywords:
acute leukemia;
central nervous system leukemia;
tumor necrosis factor-?
- From:Journal of Applied Clinical Pediatrics
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of tumor necrosis factor-?(TNF-?) in serum and cerebrospinal fluid(CSF) of children with acute lymphoblastic leukemia (ALL) and acute myelogenous leukemia(AML) and its clinical significance.Methods TNF-? in serum and CSF were measured by radioimmunoassay and CSF samples were obtained from 31 cases of childhood acute leukemia before treatment, on complete remission(CR), and continuous CR.Results Serum TNF-? was in ALL and AML before treatment [(24.35?4.84) pmol/L and(28.65?5.12) pmol/ L],which were significantly higher than those of healthy controls[(11.2 8? 1.69) pmol/L, P
