Relationship among insulin-like growth factor 1、insulin-like growth factor binding protein 3 and human fetal development
- VernacularTitle:胰岛素样生长因子1及胰岛素样生长因子结合蛋白3与胎儿宫内生长发育的关系
- Author:
xian-ping, HONG
;
li-hong, JIANG
;
ge-li, LIU
- Publication Type:Journal Article
- Keywords:
insulin-like growth factor 1;
insulin-like growth factor binding protein 3;
appropriate for gestational age;
small for gestational age
- From:Journal of Applied Clinical Pediatrics
2004;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship among insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3(IGFBP-3) and birth weight, length and placental weight and to discuss the endocrine factors which affected fetal growth by assaying levels of IGF-1、IGFBP-3 in umbilical cord serum.Methods The neonates were divided into appropriate for gestational age infant(AGA) and small for gestational age infant(SGA) according to birth weight and gestation. The birth weight, length and placental weight of neonates were measured and at meantime the levels of IGF-1 and IGFBP-3 were assayed by immunoradiometric assay.Results 1.There were 105 neonates, including 79 AGA and 26 SGA. There were significantly statistical differences in birth weight, length and placental weight (all, P
