Comparison of intravenous and oral indomethacin for treating preterm infants with patent ductus arteriosus
- VernacularTitle:静脉注射和口服吲哚美辛治疗早产儿动脉导管未闭疗效比较
- Author:
chang-dong, LU
;
qi, LI
;
ai-lan, HE
;
yan, JIANG
- Publication Type:Journal Article
- Keywords:
indomethacin;
preterm infants;
patent ductus arteriosus;
intravenous;
oral;
side effects.
- From:Journal of Applied Clinical Pediatrics
2004;0(07):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare efficacy and side effects of intravenous versus oral indomethacin treatment for symptomatic patent ductus arteriosus (PDA) in preterm infants.Methods Fourty-nine preterm infants were reviewed retrospectively who were diagnosed as having symptomatic PDA confirmed by echocardiography.According to the using type and approach that were divided into 2 groups (intravenous group,n=21;oral group,n=28) and their doses and intervals were same.The rates of ductal closure and side effects were compared in 2 groups.Results There were no significantly different between 2 groups in single ductal closure and complicating other diseases. Soon closure of intravenous group was higher significantly than oral group [61.9 %(13/21) vs 28.6 %(8/28),P
