Clinical significance of plasma nitric oxide and cyclic adernosine monophosphate/cyclic guanosine monophosphate ratio in children with asthma
- VernacularTitle:哮喘患儿血浆一氧化氮、环磷酸腺苷/环磷酸鸟苷比值变化的临床意义
- Author:
gen, LU
;
hong-juan, WANG
;
yong-kun, HUANG
;
li, HUANG
;
yu, LIU
- Publication Type:Journal Article
- Keywords:
asthma;
nitric oxide;
cyclic adenosine monophosphate;
cyclic guanosine monophosphate;
cyclic adenosine monophosphate/cyclic guanosine monophosphate ratio
- From:Journal of Applied Clinical Pediatrics
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the clinical significance and changes of plasma nitric oxide (NO) and cyclic adernosine monophosphate(cAMP)/cyclic guanosine monophosphate(cGMP) ratio in children with asthma.Methods NO,cAMP,cGMP levels and changes of cAMP/cGMP in 40 asthmatic children in acute attack stage and restoration stage and in 23 health children were measured by nitric acid reductase method and radioimmunoassay.Results 1.the amount of NO 3-/NO 2-in the plasma of asthmatic children in acute attack stage was obviously higher than that in restoration stage and in normal control group(P0.05);6.the results of linear correlation analysis showed that there were positive correlations between plasma NO 3-/NO 2- and plasma cGMP levels in acute attack stage (r=0.401 P
