Influence of interleukin-11 on graft versus host disease and graft versus leukemia after allogenic bone marrow transplantation in acute lymphoblastic leukemic junior rats
- VernacularTitle:白细胞介素-11对急性淋巴细胞白血病幼龄小鼠骨髓移植后的影响
- Author:
yong-guo, YU
;
qing-ping, GAO
- Publication Type:Journal Article
- Keywords:
interleukin-11;
graft versus host disease;
graft versus leukemia
- From:Journal of Applied Clinical Pediatrics
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the influence of interleukin-11 (IL-11) on graft versus host disease(GVHD) and graft versus leukemia(GVL) after allogenic bone marrow transplantation and related mechanism in acute lymphoblastic leukemic(ALL) junior mice.Methods The impact of IL-11 on CD4 and CD8 T cell after transplantation was evaluated by flow cytometry;it was observed that the GVHD pathology chance of internal after transplatation in ALL junior mice;the survial time after transplantantion was recorded;the level of tumor necrosis factor-?(TNF-?) which evidently related to GVHD was evaluated by ELISA.Results IL-11 could decrease the quantity of CD4 T cell and increase CD8 T cell;IL-11 could obviously increase the survival time and decrease the level of TNF-?. After ALL junior mice transplatated,IL-11 could delay and relieve GVHD.Conclusion IL-11 can alleviate GVHD and retain the effect of GVL after allogenic bone marrow transplantation.
