Study on mutation effects of antiepileptic drugs in epileptic children
- VernacularTitle:常用抗癫药物对小儿机体诱变作用
- Author:
hai-yan, ZHU
;
ke-xian, LUO
;
zhuo-ping, GUO
;
hui-feng, ZHANG
- Publication Type:Journal Article
- Keywords:
antiepileptic drugs;
carbamazepine;
valproic acid;
mutagenicity;
sister chromatid exchange;
folic acid
- From:Journal of Applied Clinical Pediatrics
1992;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the mutagenic action of antiepileptic drugs(AEDs), and find an effective way to prevent the mutagenesis induced by AEDs,by observing the effects of AEDs on serum folic acid(FA) level and sister chromatid exchange (SCE) frequency in epileptic children.Methods Ninty epileptic children were divided into different groups on the basis of the different drugs they had taken, then detected the two indexes at different time points.Results The serum FA level and SCE frequency of the patients significantly decreased and increased after they took carbamazepine (CBZ) and valproic acid (VPA)respectively. The two indexes went back respectively when supplied with FA.Conclusions Both CBZ and VPA possess mutagenic action, yet nitrazepam does not.FA may help repair the chromosome damage and reduce the mutagenesis effects.
