The effect of intermittent deferoxamine therapy on relieving iron overload in children with ? thalassemia
- VernacularTitle:间歇应用去铁胺降低重度珠蛋白生成障碍性贫血儿童铁负荷的研究
- Author:
bo, WANG
;
yong-hong, LAI
;
guo-yu, ZHONG
;
rong-jie, YU
;
tie-zhen, YE
;
fu-xiong, CHEN
;
zhi-liang, WU
- Publication Type:Journal Article
- Keywords:
deferoxmine;
chelating agent;
? thalassemia
- From:Journal of Applied Clinical Pediatrics
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of the intermittent deferomamine(DF) therapy on relieving iron overload caused by transfusion in children with ? thalassemia.Methods Sixteen children who were finally diagnosed as ? thalassemia major were treated with deferomamine for 124 times totally to low the iron overload. The serum iron(SI), serum ferritin(SF) and urine ferritin were detected each time with radio-immunity technique and difference was compared before and after treatment. Meanwhile, weather DF involved children′s liver and renal function was observed in whole procedure.Results Iron overload exists in 16 cases of ? thalassemia major children by a long- term hypertransfusion therapy, with average level SI 33.69?6.72 mmol/L,SF 441.19? 54.70 ?g/L,urine ferritin 8.64?6.79 ?g/L. The difference was significant (paired-samples t test,t =6.173 P 0.05).Conclusion The study suggest that intermittent low-dose DF therapy is effective for iron overload caused by transfusion in ? thalassemia children, without apparent side effects.
