Expression of proliferating cell nuclear antigen in renal tissues of children with primary nephrotic syndrome
- VernacularTitle:增殖细胞核抗原在原发性肾病综合征患儿肾组织的表达
- Author:
zu-xiang, MA
;
wei-ling, ZHAO
;
xiao-jie, HE
;
zhu-wen, YI
- Publication Type:Journal Article
- Keywords:
nephrotic syndrome;
proliferating cell nuclear antigen;
cell proliferation
- From:Journal of Applied Clinical Pediatrics
1992;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of proliferating cell nuclear antigen(PCNA) in renal tissues of children with primary nephrotic syndrome(NS),and elucidate the relationship between PCNA expression and cell proliferation in renal tissues from the children with primary NS.Methods Paraffin-embedded renal biopsy tissue sections from 39 patients with primary NS were examined by immunohistochemical staining with anti-PCNA monoclonal antibody,normal renal tissue sections from 6 nephrectomized patients with nephroma were selected as control. Possible correlation between the percentage of PCNA positive cells and the pathologic type , histopathological score, clinical indices (serum albumin ,serum cholesterol ,serum creatinine and 24 hours urine protein ) before renal biopsy of NS were evaluated separately .Results The percentage of PCNA positive cells in glomeruli and tubulom terstitium of NS patients was significantly higher than that of the control (P
