The study on plasma concentration of high-dose methotrexate chemotherapy for children with acute lymphoblastic leukemia
- VernacularTitle:大剂量甲氨喋呤治疗急性淋巴细胞白血病的血药浓度研究
- Author:
Ai-dong, LU
;
Le-ping, ZHANG
;
Gui-lan, LIU
- Publication Type:Journal Article
- Keywords:
acute lymphoblastic leukemia;
methotrexate;
plasma concentration
- From:Journal of Applied Clinical Pediatrics
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship among methotrexate(MTX) plasma concentration,dosage,clinical effecicy and toxicity, and to evaluate it′s clinical significance.Methods MTX was measured by a flurorescence polarization immunoassay in plasma samples obtained from acute lymphoblastic leukemia(ALL) patients treated in different doses of MTX, and these results were analyzed combined with clinical manifestations.Results 1.The average of plasma concentration at 24 hours increased with the increasing doses of MTX. The relapse rate decreased with increased plasma concentration;2.The cerebrospinal fluid(CSF) concentrations prior to the intrathecal MTXinstillation were all below the effective concentration, so the intrathecal MTX instillation was needed;3.No severe toxicity was observed in the study, because the plasma concentration was below the high risk.Conclusion The study of MTX plasma concentration provides us an objective basis for the individualized chemotherapy.
