Changes of anticoaguration and fibrinolysis in neonatal respiratory distress syndrome
- VernacularTitle:新生儿呼吸窘迫综合征抗凝及纤溶指标变化的临床意义
- Author:
zhong-lv, YE
;
ming-zhen, CHEN
;
you, WANG
;
wei-jun, PANG
- Publication Type:Journal Article
- Keywords:
newborns;
neonatal respiratory distress syndrome;
blood coagulation;
fibrinolysis
- From:Journal of Applied Clinical Pediatrics
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of anticoagulation and fibrinolysis in neonatal respiratory distress syndrome(NRDS).Methods The levels of plasma protein C(PC),total protein S(TPS),antithrombin Ⅲ(AT-Ⅲ), D-Dimer(D-D) and von Willebrand factor(vWF) were measured with ELSIA assay and immunoturbidimetry in 27 cases NRDS, 20 cases prematures and 15 cases full-term newborns as normal controls.Results The levels of PC, TPS and AT-Ⅲ were lower, but the levels of D-D and vWF were significantly higher than those of prematures and normal controls.The PC,TPS of prematures were lower than normal controls otherwise there is no difference of AT-Ⅲ,D-D,vWF between prematures and normal controls. Conclusions There exists the activation of anticoagulation and fibrinolysis and the injury of vascular endothelium in critical NRDS, and they are early sensitive indexes for the diagnosis of disseminated intravascular coagulation(DIC).
