Changes of phosphorylated cyclic adenosine monophosphate response element binding protein and effects of GM1 on it in neonatal rat models with cerebral hypoxic-ischemia
- VernacularTitle:缺氧缺血新生鼠海马磷酸化环磷酸腺苷反应元件结合蛋白的变化及神经节苷酯对其影响
- Author:
hong-ai, ZHANG
;
ling, WANG
;
qin, LENG
;
nian-di, YANG
;
shi-zhen, ZHAO
- Publication Type:Journal Article
- Keywords:
gangliosides;
hypoxic-ischemia;
cyclic adenosine monophosphate response element binding protein;
neonatal rats
- From:Journal of Applied Clinical Pediatrics
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study changes of phosphorylated cyclic adenosine monophosphate(c-AMP) response element binding protein in hippocampus(CA1) of neonatal rats after cerebral hypoxic-ischemia(HI)and effects of gangliosides (GM1)on the p-CREB.Methods An animal model of neonatal hypoxic-ischemia brain damage was established. Changes of p-CREB in hippocampal CA1 was detected with immunohistochemical methods.Results The p-CREB levels in the CA1 of HI and GM1 groups increased transiently and then decreased quickly, but there was no significant difference between HI and GM1 group.Conclusion The p-CREB levels in the CA1 of HI group increase transiently and then decrease quickly after HI ;GM1 has little effect on p-CREB in the CA1 after HI.
