Relationship between expressions of heme oxygenase-1 and brain cell apoptosis after hypoxic-ischemia brain damage in neonatal rats
- VernacularTitle:新生大鼠缺氧缺血性脑损伤血红素氧化酶-1表达与脑细胞凋亡的关系
- Author:
nian-di, YANG
;
ling, WANG
;
yan-ping, HUI
;
qin, LENG
;
hong-ai, ZHANG
- Publication Type:Journal Article
- Keywords:
heme oxygenase-1;
apoptosis;
hypoxic-ischemia brain demage;
neonatal rat
- From:Journal of Applied Clinical Pediatrics
1994;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study expressions of heme oxygenase-1 mRNA and protein in rat hippocampus after hypoxic-ischemia brain damage(HIBD) as well as the relationship with apoptosis in brain.Methods Seven-day-old SD rats were randomly divided into hypoxic-ischemia brain damage group and sham control group.Expressions of HO-1 protein and mRNA as welll as the relationship with apoptosis after HIBD in neonatal rat were determined by immunohisochemistry and in situs hybridizaion as well as terminal deoxynucleotidy transferase mediated UTP-biotin nick end labeling(TUNEL).Results 1.In the right hippocampus,expression of HO-1 gene increased sharply at 4 h (P
