The regulatory effect of hydrogen sulfide on pulmonary artery prolife rating cell nuclear antigen and Bcl-2 in hypoxic pulmonary hypertensive rats
- VernacularTitle:硫化氢对低氧性肺动脉高压大鼠肺动脉增殖细胞核抗原及Bcl-2的调节作用
- Author:
xiao-bo, CHEN
;
jun-bao, DU
;
chun-yu, ZHANG
;
chao-shu, TANG
- Publication Type:Journal Article
- Keywords:
hydrogen sulfide;
pulmonary hypertension;
hypoxia;
r emodeling;
proliferation;
apoptosis
- From:Journal of Applied Clinical Pediatrics
1993;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the regulatory effects of hyd ro gen sulfide (H 2S) on hypoxic pulmonary hypertension and pulmonary vascular rem odeling in rats. Methods Twenty-four rats were divided into 3 groups: control group(n=8), hypoxia group(n=8), and hypoxia +NaHS group( n=8). After 21 days of hypoxia, the mean pulmonary artery pressure (mPAP) wa s measured. The weight ratio of right ventricle. left ventricle +septum (R/L+S r atio) was measured. The microstructure and ultrastrcture changes in pulmonary sm all arteries were examined. The contents of proliferating cell nuclear antigen (PCNA) and Bc l-2 protein expressions were detected by immunohistochemical assay.Resu lts Compared with rats in the control group, the mPAP increased by 45.6 % (P
