Neuroprotective effect of magnesium sulfate on neuron cell
- VernacularTitle:硫酸镁对体外培养神经元细胞的保护作用
- Author:
zhi-wei, XU
;
shen-jun, CHEN
;
zhao-hui, LU
;
shun-min, WANG
- Publication Type:Journal Article
- Keywords:
magnesium sulfate;
hippocampal neuron;
culure in vitro;
neuroprotection;
c-fos;
glutamate
- From:Journal of Applied Clinical Pediatrics
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective It has become more important to protect brain function in operation and post-operation period with the developmen of surgery therapy for congenital heart surgery.Methods The primary cultured neuron cell of l8-day-pregnan embryoid Sprague-Dawley rat's hippocampus has been selected as the experimental material.The experimental concentration of magnesium sulfate will be 0 mmol/L,1 mmol/L,2 mmol/L,4 mmol/L;0 mmol/L is for control group.Selecting c-fos protein as target for primary antibody.Results After immunohistochemistry procedure,we found the mortality of neuronal cultures with magnesium sulfate in different concentration was 89.47 %,49.35 %,52.56 %,90.67 %(P
