Progress of photodynamic therapy combined with anti - VEGF for patients with choroidal neovascularization
10.3980/j.issn.1672-5123.2016.11.16
- VernacularTitle:光动力疗法联合抗血管内皮生长因子药物治疗脉络膜新生血管的进展
- Author:
Yang, LIU
;
Lei, LI
- Publication Type:Journal Article
- Keywords:
choroidal neovascularization;
photodynamic therapy;
anti-vascular endothelial growth factor;
combined modality therapy
- From:
International Eye Science
2016;16(11):2048-2052
- CountryChina
- Language:Chinese
-
Abstract:
Choroidal neovascularization( CNV) is a common severe complication of ocular fundus diseases, with great potentiality to cause blindness. The treatments of CNV include photodynamic therapy ( PDT ) and anti-vascular endothelial growth factor( VEGF) therapy. However, PDT produces little visual benefits, and may result in ischemia, inflammatory responses, even the secondary expressions of VEGF. Anti-VEGF therapy sustained visual efficiency by repeated injections, causing economic burden and adverse effects related to injection. Recently, PDT combined with anti-VEGF therapy has progressed in laboratory and clinical research. Therefore, the combined modality therapy became one of the treatment options for CNV. In order to reduce the side effects of mono -therapy, further study is required to determine appropriate combinations and dosage.
