Progress in placental growth factor in ocular neovascular disease
10.3980/j.issn.1672-5123.2016.11.17
- VernacularTitle:胎盘生长因子在新生血管性眼病中的研究进展
- Author:
Jun, ZHOU
;
Tao, LIU
- Publication Type:Journal Article
- Keywords:
placental growth factor;
vascular endothelial growth factor receptor;
anti-VEGF drugs;
ocular neovascularization
- From:
International Eye Science
2016;16(11):2053-2058
- CountryChina
- Language:Chinese
-
Abstract:
Neovascularization is the main cause of blindness, such as diabetic retinopathy, retinopathy of prematurity and age - related macular degeneration. Vascular endothelial growth factor( VEGF) plays an important role in the formation of angiogenesis, and is considered to be the most potent angiogenic growth factor. Placental Growth Factor(PlGF) is one of the VEGF family, which play a crucial role in endothelial cell proliferation and migration, angiogenesis, and immune - mediated inflammation. Meanwhile, PlGF is specifically expressed in pathological angiogenesis, but not in normal blood vessels. In recent years, there has been increasing attention to PlGF, therefore this article reviews the role of PlGF in neovascular ocular diseases.
