Recent Advances in Molecular Imaging of Premalignant Gastrointestinal Lesions and Future Application for Early Detection of Barrett Esophagus.
- Author:
Kwang Hyun KO
1
;
Na Young HAN
;
Chang Il KWON
;
Hoo Keun LEE
;
Jong Min PARK
;
Eun Hee KIM
;
Ki Baik HAHM
Author Information
1. Digestive Disease Center, CHA Bundang Medical Center, CHA University, Seongnam, Korea. hahmkb@cha.ac.kr
- Publication Type:Review
- Keywords:
Gastrointestinal premalignant lesions;
Barrett esophagus;
Imaging mass spectrometry;
Biological markers
- MeSH:
Adenocarcinoma;
Barrett Esophagus*;
Diagnostic Imaging;
Mass Spectrometry;
Metabolomics;
Molecular Imaging*;
Narrow Band Imaging;
Optical Imaging;
Tomography, Optical Coherence;
Biomarkers
- From:Clinical Endoscopy
2014;47(1):7-14
- CountryRepublic of Korea
- Language:English
-
Abstract:
Recent advances in optical molecular imaging allow identification of morphologic and biochemical changes in tissues associated with gastrointestinal (GI) premalignant lesions earlier and in real-time. This focused review series introduces high-resolution imaging modalities that are being evaluated preclinically and clinically for the detection of early GI cancers, especially Barrett esophagus and esophageal adenocarcinoma. Although narrow band imaging, autofluorescence imaging, and chromoendoscopy are currently applied for this purpose in the clinic, further adoptions of probe-based confocal laser endomicroscopy, high-resolution microendoscopy, optical coherence tomography, and metabolomic imaging, as well as imaging mass spectrometry, will lead to detection at the earliest and will guide predictions of the clinical course in the near future in a manner that is beyond current advancements in optical imaging. In this review article, the readers will be introduced to sufficient information regarding this matter with which to enjoy this new era of high technology and to confront science in the field of molecular medical imaging.
