Comparison of effects of botulinus toxin of type A and complete resection of the periorbital muscle for idiopathic blepharospasm
10.3980/j.issn.1672-5123.2016.10.47
- VernacularTitle:A型肉毒素注射与眶周全肌切除术治疗特发性眼睑痉挛的比较
- Author:
Xiao-Hong, XU
;
Kai, XU
;
Qi, PENG
;
Ying-Chun, XUE
;
Xue-Fei, PAN
- Publication Type:Journal Article
- Keywords:
idiopathic blepharospasm;
botulinus toxin of type A;
complete resection of the periorbital muscle;
effect
- From:
International Eye Science
2016;16(10):1962-1964
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To compare the effectiveness of botulinus toxin of type A and complete resection of the periorbital muscle on idiopathic blepharospasm.
● METHODS: Patients with idiopathic blepharospasm and having undergone either of two procedures from Dec. 2010 to Jun. 2015 were selected ( 60 patients ) . Among them, group A (30 patients, 60 eyes) underwent botulinus toxin of type A, group B (30 patients, 60 eyes) underwent complete resection of the periorbital muscle.
●RESULTS: ln group A, the patients with complete response, obvious response, partial response, and no response were 36(60. 0%), 20(33. 3%), 2(3. 3%) and 2 (3. 3%) cases respectively. ln group B, the patients with complete response, obvious response, partial response, and no response were 16(26. 7%), 24(40. 0), 12(20. 0%) and 8 ( 13. 3%) cases respectively. The difference was statistically significant ( Z = - 2. 968, P = 0. 003 ). The relapse rate of group A and group B were 93. 3% and 20. 0% after 6mo, the difference was statistically significant (χ2=32. 851, P<0. 001).
●CONCLUSION: The botulinus toxin injection of type A is effective for idiopathic blepharospasm. But recurrence rate is high after 6mo. Complete resection of the periorbital muscle have long-term efficacy for idiopathic blepharospasm. It′s a supplementary therapy after idiopathic blepharospasm recurrence.
