Histopathology of minor salivary gland biopsies in Gougerot-Sj\xf6gren syndrome combined to rheumatoid arthritis
- Author:
Ngoc Vinh Nguyen
- Publication Type:Journal Article
- Keywords:
Gougerot-Sj\xf6gren syndrome;
rheumatoid arthritis;
biopsy;
minor salivary gland
- MeSH:
Arthritis;
Rheumatoid/ pathology;
diagnosis;
Sjogren's Syndrome/ pathology;
diagnosis;
Salivary Glands;
Minor/ pathology
- From:Journal of Medical Research
2007;53(5):134-138
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Background: The minor salivary gland biopsy is an important diagnostic criterion of Gougerot-Sj\xf6gren syndrome. Objective: To describe histopathological characteristics of minor salivary gland of Gougerot-Sj\xf6gren syndrome combined to rheumatoid arthritis. Subjects and method: A prospective, descriptive, cross-sectional study included 108 patients with rheumatoid arthritis, who treated at Department of Rheumatology of Bach Mai hospital, from 1998 to 2003. The patients were divided into 2 groups: 50 patients with Gougerot-Sj\xf6gren syndrome and 58 patients without Gougerot-Sj\xf6gren syndrome. Results: Characteristics of minor salivary gland biopsy were lymphocytic infiltration of minor salivary glands (96%) with various distribution: periductal (86%), periacinic (72%), perivascular (36%). 78% of cases were plasmocytic infiltration, with periductal distribution (70%). 82% of cases were 3, 4 stages according to Chilsom clsssification. 67.5% of cases had ductal abnormality, glandular atrophy (62%), vascular edema (58%). Conclusion: Incidence of 3, 4 stages according to Chilsom classification was 82% in rheumatoid arthritis patients with Gougerot-Sj\xf6gren syndrome.
