Research progress of Manganese-enhanced MRI optic nerve tracing in vivo

VernacularTitle:锰离子增强MRI活体视神经示踪技术研究进展
Author: Yao, CHEN
Publication Type:Journal Article
Keywords: Manganese; MRI; Optic nerve
From: Chinese Journal of Experimental Ophthalmology 2016;34(6):562-565
CountryChina
Language:Chinese
Abstract: Manganese-enhanced MRI (MEMRI) optic nerve tracing in vivo is a technology which can reflect the axonal transport status and visual pathway connection by utilizing divalent manganese ion's transportability in axons and its characteristics of paramagnetism,and such potential optic nerve tract-tracing technique has been widely used in ophthalmologic research.Mn2+ enters the neurons through the voltage-gating Ca2+ channel and is transported by microtubule system which is not depended on cellular electric activity.However,the trans-synaptic transport of Mn2+ relies on membrane potential.Taking advantages of MEMRI,optic nerve injury-related research could be implemented.Mn2+ is an intracellular contrast agent with metal toxicity,so low dose,fractionated,targeted delivery of Mn2+ is recommended to alleviate the adverse effects of Mn2+.Herein,the mechanism of divalent manganese ion optic nerve tracing,application of MEMRI in ophthalmologic research field,drug delivery approach of divalent Mn2+ and its toxicity were summarized.