Interferon-gamma (IFN-gamma) increases CD1 expression through inhibition of IL-10 secretion from M.leprae-infected macrophages of lepromatous leprosy.
- Author:
Seong Beom LEE
1
;
Se Kon KIM
;
Hye Jeong LEE
;
Hang Kye SHIN
;
Jong Pill KIM
;
Young Hoon KO
;
Sung Hwa KIM
;
Gue Tae CHAE
Author Information
1. Institute of Hansen's Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, Korea.
- Publication Type:Original Article
- Keywords:
Leprosy;
Macrophage;
CD1;
IFN-gamma;
IL-10
- MeSH:
Antigen-Presenting Cells;
Glycolipids;
Granuloma;
Immunity, Cellular;
Interferon-gamma*;
Interleukin-10*;
Leprosy;
Leprosy, Lepromatous*;
Macrophages*
- From:Korean Leprosy Bulletin
2000;33(2):47-54
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The CD1 system is a novel antigen-presenting system for T cell recognition of lipid and glycolipids in antimicrobial immunity. Lepromatous leprosy is characterized by lack of cell-mediated immunity against M.leprae. The lack of cell-mediated immunity in lepromatous leprosy has been suggested to be correlated with weak CD1 expression on antigen presenting cells. In order to define how CD1 is down-regulated on M. leprae-infected antigen-presenting cells, we examined effects of interferon-gamma(IFN-gamma) on interleukin-10 (IL-10) secretion and CD1 expression of M.leprae-infected macrophages from granuloma of lepromatous leprosy. Our results showed that a significant trend of increased CD1 expression in response to decresed IL-10 secretion from M.leprae-infected macrophages by IFN-gamma. These results suggest that the local cytokine milieu, especially the balance between IFN-gamma and IL-10, is an important determinant in the regulation of CD1 in lepromatous lesions.
