Effects of 1 g/L topical cyclosporine A in preventing pterygium recurrence after pterygium surgery

VernacularTitle:1g/L环孢霉素A滴眼液在预防胬肉复发中的临床应用
Author: Han-Yuan, YE ; Jin-Mei, HE
Publication Type:Journal Article
Keywords: topical cyclosporine A; pterygium excision; recurrence; complications
From: International Eye Science 2016;16(10):1965-1967
CountryChina
Language:Chinese
Abstract: AIM: To investigate the efficacy of 1g/L topical cyclosporine A ( tCsA ) in preventing the recurrence of pterygium after pterygium excision and conjunctival flap rotation technique.
●METHODS:Fifty-eight patients (58 eyes) with primary pterygium were included in this prospective study. All eyes were operated with pterygium excision and conjunctival flap rotation technique, and divided into treatment and control group according to whether be treated with 1g/L tCsA eye drops after operation. The operated patients were followed up for 1y to assess the recurrence of pterygium.
●RESULTS: After surgery, the difference between the tCsA treatment and control group were statistically significant in the Schirmer l test results (9. 93 ± 1. 59mm/5min vs 8. 47±1. 53mm/5min, P<0. 001). The Schirmer l test results increased after tCsA treatment for patients assigned to the treatment group. The pterygium recurred in 3 of 28 eyes (10%) in the treatment group and 11 of 30 eyes (39%) in the control group (P=0. 029).
●CONCLUSION:tCsA eye drops are safe and effective for medical treatment to reduce rates of recurrence after pterygium surgery.