HLA-A, B and DRB1 Genes Related with Susceptibility and Type of Hansen's Disease.
- Author:
Gue Tae CHAE
1
;
Seong Beom LEE
;
Tae Jin KANG
;
Jong Pill KIM
;
Young Hoon KO
Author Information
1. Institute of Hansen's Disease, Department of Pathology, College of Medicine, The Catholic University of Korea, Korea.
- Publication Type:Original Article
- MeSH:
Alleles;
Diagnosis;
Gyeonggi-do;
HLA-A Antigens*;
Korea;
Leprosy*;
Rivers;
Seoul
- From:Korean Leprosy Bulletin
2000;33(2):67-78
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
To find out whether the susceptibility to Hansen's disease are associated with HLA genes, serological and nucleotide typing of HLA-A, B, and DRB1 alleles have been conducted in 301 Hansen's disease patients[190 Multibacillary cases(MB, LL/BL), 111 Paucibacillary cases(PB, TT/BT) confirmed at the time of diagnosis, almost of them were treated with Multidrug therapy] and 928 healthy controls from a population in Seoul and Northern area of Han River in Kyunggi Province, Korea. HLA-A30[relative risk(RR) 1.58, chi-square=4.89, P=0.04] was significantly associated with Hansen's disease. In contrast to HLA-B27(RR 0.20, chi-square=11.34, P=0.0002), which was negatively associated with Hansen's disease as a whole, in MB and PB separately, HLA-B52(RR 1.97, chi-square=6.89, P=0.002) and B46(RR 1.63, chi-square=4.84, P=0.04) were significantly increased in Hansen's disease. DRB1*02 was associated with MB(LL/BL)[RR 1.96, chi-square=13.47, P=0.0004] but not with PB(TT/BT). Further works about oligonuceotide typing of DQA,B, and DPB1 are ongoing. High resolution study to define DRB1*02 alleles will be performed.
