Clinical effect of compound anisodine on patients with paralytic strabismus and the influence on malondialdehyde and superoxide dismutase
10.3980/j.issn.1672-5123.2016.10.29
- VernacularTitle:复方樟柳碱治疗麻痹性斜视的疗效及对丙二醛和超氧化物歧化酶的影响
- Author:
Yang, YANG
;
Yin-Qun, ZHOU
- Publication Type:Journal Article
- Keywords:
compound anisodine;
paralytic strabismus;
superoxide dismutase;
clinical effect;
malondialdehyde
- From:
International Eye Science
2016;16(10):1902-1904
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the clinical effect of compound anisodine on patients with paralytic strabismus and the influence on malondialdehyde ( MDA ) and superoxide dismutase ( SOD) .
●METHODS: Seventy cases diagnosed with paralytic strabismus from Jun. 2008 to Dec. 2014 were selected as treatment group; another 70 cases with paralytic strabismus from Oct. 2000 to Jan. 2008 were chosen as control group. The control group was given with conventional therapy, and treatment group was additionally injected with compound anisodine subcutaneously on the basis of the control group. Treatment lasted for two courses about 28days. The effect of compound anisodine on patients with paralytic strabismus was evaluated and the serum level of MDA and SOD was also measured before and after treatment.
●RESULTS: ln treatment group, 54 cases were cured (77%), 14 cases improved (20%) and 2 cases had no response ( 3%) and total efficiency reached to 97%. ln control group, 32 cases were cured ( 46%) , 21 cases improved ( 30%) and 17 cases had no response ( 24%) and total efficiency was 76%. The cure rate and total efficiency of treatment group were significantly higher than that of control group (P<0. 05). Before treatment, the level of SOD and MDA was equal in two groups. After treatment, increased SOD level and decreased MDA level was observed in both groups. However, compound anisodine were significantly increased SOD level and reduced MDA level when compared with conventional therapy (P<0. 05).
●CONCLUSION: The compound anisodine shows the beneficial effect on patients with paralytic strabismus. Compound anisodine may exert the effect via increasing SOD and reducing MDA.
