Efficacy of two anti-VEGF drugs for age-related macular degeneration

VernacularTitle:两种抗 VEGF 药物治疗渗出性年龄相关性黄斑病变的疗效
Author: Xi-An, CAI ; Hui, PENG
Publication Type:Journal Article
Keywords: age -related macular degeneration; ranibizumab; conbercept
From: International Eye Science 2016;16(8):1501-1503
CountryChina
Language:Chinese
Abstract: ? AIM: To evaluate efficacy of Ranibizumab and Conbercept for wet age-related macular degeneration ( wAMD) .?METHODS: This was a retrospective case series study. Thirty patients ( 30 eyes ) with wAMD were enrolled to receive intravitreal injections of ranibizumab (0.5mg) on 3 consecutive monthly schedule and 28 patients (30 eyes) with wAMD were enrolled to receive intravitreal injections of conbercept ( 0.5mg ) on 3 consecutive monthly schedule.Best corrected visual acuity ( BCVA ), optic coherence tomography ( OCT ) measurement were compared at 1mo after injections.?RESULTS: One month after every injection, the BCVA increased while the central macular thickness ( CMT ) decreased compared with those before treatment in group A and B (P<0.05).BCVA and CMT changes between two groups were no statistically different (P>0.05).?CONCLUSION:Ranibizumab and conbercept therapy can control the prognosis of wAMD and improve the vision effectively. There is no statistical difference on the curative effect between two drugs for 3mo.