Mechanism of DJ -1 against oxidative stress and its roles in the pathogenesis of age -related macular degeneration and Fuchs endothelial corneal dystrophy
10.3980/j.issn.1672-5123.2016.8.15
- VernacularTitle:DJ－1抗氧化应激相关机制在年龄相关性黄斑变性和角膜内皮营养不良发生中的作用
- Author:
Ya-Lan, ZHOU
;
Jun, ZENG
;
Bai-Hua, CHEN
- Publication Type:Journal Article
- Keywords:
DJ-1;
oxidative stress;
reactive oxygen species;
eye diseases;
Fuchs endothelial corneal dystrophy;
age-related macular degeneration
- From:
International Eye Science
2016;16(8):1465-1468
- CountryChina
- Language:Chinese
-
Abstract:
?DJ-1 has been reported to act as aredox-activated chaperone and sensor of oxidative stress participated in a variety of activities in cellular, playing an important role in resisting oxidative stress, regulating signaling pathways and gene transcription, and maintaining mitochondria dynamic balance. DJ -1 is closely related to the occurrence and development of various diseases. Recently, the effect of DJ-1 in eye diseases has drawn more attention, and researchers have found its significant role of resistance to oxidative stress in the pathogenesis of Fuchs endothelial corneal dystrophy ( FECD) and age-related macular degeneration ( AMD ) .This review will state the mechanism of DJ-1 against oxidative stress and its role in the development of eye diseases.
