Longitudinal analysis of retinal nerve fiber layer thickness measurement by spectral-domain optical coherence tomography in normals and in glaucoma patients with or without progression
10.3980/j.issn.1672-5123.2016.8.26
- VernacularTitle:应用 SD－O CT 纵向比较正常人群和青光眼进展及非进展人群的 RNFL 厚度
- Author:
Xin-Hui, GUAN
;
Li, LI
;
Yong, LIANG
- Publication Type:Journal Article
- Keywords:
primary open angle glaucoma;
progression;
optical coherence tomography;
retinal nerve fiber layer
- From:
International Eye Science
2016;16(8):1504-1507
- CountryChina
- Language:Chinese
-
Abstract:
Abstract?AIM:To compare the loss of peripapillary retinal nerve fiber layer ( RNFL ) thickness measurements by spectral-domain optical coherence tomography ( SD -OCT ) in healthy individuals and glaucoma patients with or without progression.? METHODS: A total of 60 eyes, comprising 36 glaucomatous eyes with primary open angle glaucoma (POAG) and 24 healthy controls, were included in the study over a 2-year period.All eyes underwent at least 4 serial RNFL measurements performed by Cirrus OCT every half a year over a period of 2a.Visual field ( VF) testing was performed by using the Swedish interactive threshold algorithm( SITA) Standard 30-2 program of the Humphrey field analyzer within the same week as the optic disc/RNFL photography. By masked comparative analysis of VF test results and optic disc/RNFL photographs, the eyes were classified into non -progressive and progressive glaucoma cases. Longitudinal loss of RNFL thickness was compared.?RESULTS: The mean follow-up time was 2.1 ±0.3a. Seventeen from 36 subjects were identified as progressors. Mean rates of change in average RNFL thickness were significantly higher for progressors compared with nonprogressors (2.46μm/a vs.1.21μm/a;P <0.001 ). Inferior quadrant RNFL thickness were significantly correlated with MD reduction in glaucoma eyes with progression(r=0.423, P=0.03).? CONCLUSION: Longitudinal measurements of RNFL thickness using SD-OCT show a pronounced reduction in patients with progression compared with patients without progression.Inferior RNFL thickness parameters might be more important in discriminating eyes with progressive glaucomatous optic nerve damage.
