Comparison study of corneal epithelial remodeling after TransPRK and Epi-LASIK for myopia
10.3980/j.issn.1672-5123.2016.8.30
- VernacularTitle:TransPRK 与 Epi－LASIK 术后角膜上皮重塑的对比研究
- Author:
Fan-Chao, MENG
;
Jie, HOU
;
Yu-Lin, LEI
;
Xiu-Yun, ZHENG
- Publication Type:Journal Article
- Keywords:
myoipa;
excimer laser;
full laser;
photorefractive keratectomy;
corneal epithelium
- From:
International Eye Science
2016;16(8):1519-1521
- CountryChina
- Language:Chinese
-
Abstract:
Abstract?AIM: To compare the changes in epithelial thickness profile following TransPRK and Epi-LASIK for myopia.? METHODS: In this prospective non -randomized controlled study, 76 right eyes of 76 myopic patients with the spherical equivalent refraction -1.25 to -6.00D were included under the informed consent. The eyes were divided into TransPRK group for 43 eyes and Epi-LASIK group for 33 eyes. Epithelial thickness was measured using spectral-domain optical coherence tomography at different corneal zones ( central, 2mm; paracentral, 2-5mm;and mid-peripheral, 5-6mm) preoperatively and at 1, 3, and 6mo postoperatively. The results were compared between the two groups.?RESULTS: The epithelium were thicker at 3 and 6mo after surgery compared to preoperative measurements in the two groups (all P<0.05).In TransPRK group, the epithelial thickness at 3 and 6mo demonstrated a negative meniscus-like lenticular pattern with lesser thickening centrally and progressively great thickening centrifugally (F3mo =-2.687,P=0.027;F6mo =-2.908,P=0.000).No statistically significant change was detected among the three zones in Epi-LASIK group (F=1.365, P=0.237). The epithelial thickness was thicker in the TransPRK group compared to the Epi-LASIK group mid-peripherally ( P<0.05) .? CONCLUSION: Significant epithelial thickening was observed after TransPRK and Epi-LASIK.It was showed a lenticular change with more thickening mid-peripherally after TransPRK than Epi -LASIK. Wound healing and inflammation may account for differences in the effect on epithelial thickness change by both surgeries.
