Association of the single nucleotide polymorphisms in the calcitonin receptor-like receptor gene with primary angle closure in a Han Chinese population
10.3980/j.issn.1672-5123.2016.8.46
- VernacularTitle:CRLR 基因单核苷酸多态性与原发性前房角关闭人群的关联研究
- Author:
Bai, QIN
;
Hai-Hong, SHI
;
Rong-Rong, ZHU
;
Jun-Fang, ZHANG
;
Mei, YANG
;
Huai-Jin, GUAN
- Publication Type:Journal Article
- Keywords:
primary angle closure;
calcitonin receptor-like receptor gene;
single nucleotide polymorphism;
Han Chinese population
- From:
International Eye Science
2016;16(8):1570-1572
- CountryChina
- Language:Chinese
-
Abstract:
?AIM: To study the association of the single nucleotide polymorphism ( SNP) rs1157699 in the calcitonin receptor-like receptor ( CRLR ) gene with primary angle closure ( PAC) in a Han Chinese population.?METHODS: All samples, involved 232 PAC cases and 306 controls, were obtained from an epidemiologic survey conducted in Funing, Jiangsu Province, China. Genotyping were carried out by TaqMan-MGB probe using the real time quantitative polymerase chain reaction system to study the relationship between SNP of rs1157699 in CRLR gene and PAC.?RESULTS: The prevalence of CRLRrs1157699 genotype was 67.4%, 30.0%, 2.6% for CC, CT, TT in cases, and 71.3%, 27.0%, 1.7% in controls respectively.There was no difference between the two groups in the distribution of genotype and allele frequencies of rs1157699 (P>0.05).?CONCLUSION:Our results do not support a significant role for rs1157699 in CRLR with PAC.
