Role of hypoxia-inducible factor-1 alpha in retinoblastoma development
10.3980/j.issn.1672-5123.2016.8.18
- VernacularTitle:低氧诱导因子－1α在视网膜母细胞瘤发生发展中作用的研究进展
- Author:
Jia-Li, HU
;
Yu, GAO
- Publication Type:Journal Article
- Keywords:
hypoxia -inducible factor -1 alpha;
retinoblastoma;
vascular mimicry
- From:
International Eye Science
2016;16(8):1477-1479
- CountryChina
- Language:Chinese
-
Abstract:
?Retinoblastoma is a common eye malignant tumor which has high degree of malignancy.The traditional treatment methods are destructive, and the prognosis is poor. Hypoxia-inducible factor-1αhighly express in retinoblastoma and regulate the development and progression of retinoblastoma ( by influencing the proliferation and differentiation of tumor cells and involving in the generation of vascular mimicry ) . This article reviewed the role of hypoxia inducible factor-1αin the development of retinoblastoma which will initiate a new avenue for the treatment of retinoblastoma.
