Concentrations of serum VEGF and bFGF in Mongolia patients with diabetic retinopathy
10.3980/j.issn.1672-5123.2016.7.27
- VernacularTitle:VEGF 和 bFGF 在蒙古族糖尿病视网膜病变中的表达
- Author:
Jun, ZHANG
;
Sen-Yu, LIU
- Publication Type:Journal Article
- Keywords:
Mongolia;
diabetes;
vascular endothelial growth factor;
basic fibroblast growth factor
- From:
International Eye Science
2016;16(7):1313-1315
- CountryChina
- Language:Chinese
-
Abstract:
AIM: To investigate the changes of serum angiogenic factors including vascular endothelial growth factor (VEGF) and basic fibroblast growth factor ( bFGF) in Mongolia patients with diabetic retinopathy ( DR) and to explore their roles in the progress of DR.
METHODS: Eighty - three patients with diabetes were divided into three groups according to the retinopathy, no DR group ( NDR, 25 cases), background DR ( NPDR, 31 cases) and proliferative DR group (PDR, 27 cases), and 36 age - matched healthy people ( control group) were selected. Serum concentrations of VEGF and bFGF were measured using ELISA method.
RESULTS: In Mongolia patients with diabetes, the serum concentrations of VEGF and bFGF were higher than those in control group; the serum concentrations of VEGF and bFGF in PDR group was higher than those of NDR and NPDR group (P< 0. 05); the concentrations of VEGF and bFGF in NPDR group was higher than that of NDR group (P<0. 05).
CONCLUSION: High level of VEGF and bFGF may be the important pathogenic factors for DR in Mongolia patients.
