Progress on Nrf2 pathway in diabetic retinopathy
10.3760/cma.j.issn.2095-0160.2016.05.017
- VernacularTitle:Nrf2通路在糖尿病视网膜病变中的研究进展
- Author:
Siyuan, ZHANG
- Publication Type:Journal Article
- Keywords:
Nuclear factor erythroid 2-related factor 2;
Diabetic retinopathy;
Oxidative stress;
Vascular endothelial growth factor
- From:
Chinese Journal of Experimental Ophthalmology
2016;34(5):471-475
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic retinopathy (DR) is a serious complication of diabetes mellitus,which leads to vision loss or even blindness.Nuclear factor erythroid 2-related factor 2 (Nrf2) is a redox-sensitive transcription factor and plays an important role in oxidative stress and tissue injury associated with inflammation.More and more evidences show that Nrf2 play an important role in the onset and development of DR.This paper reviewed the role of Nrf2 pathway in diabetes mellitus and DR,and correlation between Nrf2 pathway and vascular endothelial growth factor (VEGF) expression.
