Research progression of Fractalkine/cx3cr1 and microglia in retina diseases
10.3760/cma.j.issn.2095-0160.2015.09.021
- VernacularTitle:Fractalkine/cx3cr1与小胶质细胞在眼底疾病中的研究进展
- Author:
Juanjuan, LI
- Publication Type:Journal Article
- Keywords:
Fractalkine;
Cx3cr1;
Microglia;
Retina
- From:
Chinese Journal of Experimental Ophthalmology
2015;33(9):861-864
- CountryChina
- Language:Chinese
-
Abstract:
Fractalkine (Fkn) is the only member of CX3C subfamily of chemokine currently found,cx3cr1 is its specific receptor.Fkn/cx3cr1 is involved in inflammation,cancer,autoimmune diseases,allergy,acquired immune deficiency syndrome and other diseases,while its variety of pathophysiological role is accomplished by microglia.Functions of Fkn/cx3cr1 and microglia in age-related macular degeneration,acute light damage disease,retinal vascular disease,diabetic retinopathy disease,uveitis and other retina disease were reviewed in this article.
