Regulation of Toll-like receptors in fungal keratitis
10.3760/cma.j.issn.2095-0160.2015.10.019
- VernacularTitle:Toll样受体在真菌性角膜炎中的调控作用
- Author:
Luping, WANG
- Publication Type:Journal Article
- Keywords:
Keratitis,fungal;
Toll-like receptors;
Signal transduction;
Nod-like receptors;
Dectin-1;
Immune tolerance
- From:
Chinese Journal of Experimental Ophthalmology
2015;33(10):953-956
- CountryChina
- Language:Chinese
-
Abstract:
Fungal keratitis (FK) ,a potential blinding disease,has been difficult to treat due to the limited number of approved antifungal drugs and the taxing dosing regimen.Toll-like receptors (TLRs) function as the pattern recognition receptors (PRRs) in mammals and play an essential role in the recognition of fungal components.There is a great amount of evidence that TLRs initiate the innate immunity in the FK.Furthermore, TLRs also play roles in shaping fungal-specific humoral and cellular adaptive immune responses.This review described the recent advances in interaction between TLRs and non-TLRs signal transduction,negative regulator and function of TLRs in corneal fungal infection.
