Regulation roles of COUP transcription factors in the development of embryonic eye
10.3760/cma.j.issn.2095-0160.2015.08.017
- VernacularTitle:鸡卵白蛋白上游启动子转录因子对胚眼发育的调控作用
- Author:
Yaru, DU
- Publication Type:Journal Article
- Keywords:
COUP transcription factor Ⅰ;
COUP transcription factor Ⅱ;
Development of embryonic eye;
Retinal development
- From:
Chinese Journal of Experimental Ophthalmology
2015;33(8):751-754
- CountryChina
- Language:Chinese
-
Abstract:
Chicken ovalbumin upstream promoter-transcription factors (COUP-TFs) are the orphan receptors of the steroid/thyroid hormone receptor superfamily.These factors include COUP-TF Ⅰ and COUP-TF Ⅱ,which play critical roles in embryonic development,organogenesis,neurogenesis and cellular differentiation.Many studies showed that COUP-TFs were also involved in the development of embryonic eye.More attention has been paid to the issue that mutations of COUP-TFs genes lead to phenotypes of coloboma,small eyes,optic atrophy,eye retardation,strabismus,and amblyopia.However,the mechanisms of COUP-TFs regulating the development of embryonic eye are not clear.The origin,molecular struture,classification,biological functions,mechanisms of regulating the target genes transcription and development of embryonic eye of COUP-TFs were reviewed.
