Research advances on treatment of vitreomacular adhesion with gene recombinant ocriplasmin
10.3760/cma.j.issn.2095-0160.2014.12.020
- VernacularTitle:基因重组纤溶酶ocriplasmin治疗玻璃体黄斑粘连的研究进展
- Author:
Zhidong, LI
- Publication Type:Journal Article
- Keywords:
Ocriplasmin;
Vitreomacular adhesion;
Posterior vitreous detachment;
Clinical trial
- From:
Chinese Journal of Experimental Ophthalmology
2014;32(12):1144-1147
- CountryChina
- Language:Chinese
-
Abstract:
Vitreous retinal interface abnormalities are associated with many macular diseases.The main approach of treatment is to release the vitreomacular adhesion with pars plana vitrectomy.Because of its complication and limitation,researches of pharmacologic posterior vitreous detachment (PVD) were undertaken.Gene recombinant ocriplasmin was proved by several experiments and clinical trials by inducing a complete PVD,showing its promising prospect.This article reviewed the literatures of ocriplasmin,including pathobiology in treatment of vitreomacular adhesion,pharmacokinetics,vitreodynamics,experimental studies and clinical trials and adverse events.
