Current research in the relationship between Th1/Th17-related cytokines and autoimmune uveitis
10.3760/cma.j.issn.2095-0160.2014.10.017
- VernacularTitle:自身免疫性葡萄膜炎与Th1、Th17相关细胞因子的研究进展
- Author:
Wei, CHEN
- Publication Type:Journal Article
- Keywords:
Uveitis/immunology;
Autoimmune;
CD4+T helper;
Cytokine
- From:
Chinese Journal of Experimental Ophthalmology
2014;32(10):943-949
- CountryChina
- Language:Chinese
-
Abstract:
Human autoimmune uveitis encompasses a diverse group of common ocular inflammatory diseases.Unknown factors trigger the breakdown of self-tolerance and subsequently lead to the irreversible vision impairment.So the explore and research has never ceased for a long time.Previous study indicated that T helper lymphocyte 1 (Th1) plays a key role in the pathogenesis and development of human autoimmune uveitis.But recently accumulating evidences from both animal and clinical studies suggest that Th17 participates in the pathological mechanism of human autoimmune uveitis.Studies showed that Th1 and Th17 determine the pathological process by the regulation signal of specific cytokines and transcription factors.More and more evidences revealed that Th1 and Th17 are the predominant influences in induction of uveitis.Unveiling the roles of Th1/Th17-related cytokines will help to elucidate the mechanism and progression of uveitis.Recent findings of Th1/Th17-related cytokines regarding pathogenesis and regulation attributed in uveitis were summarized and the novel viewpoint of treatments was discussed.
