Advance of immunological pathogenesis of glaucoma and glaucomatous neuropathy
10.3760/cma.j.issn.2095-0160.2013.03.021
- VernacularTitle:青光眼及其视神经损害的免疫学研究进展
- Author:
Ze-lin, YIN
- Publication Type:Journal Article
- Keywords:
Glaucoma;
Retinal ganglion cell;
Immunology;
Autoantibody;
Cytokine
- From:
Chinese Journal of Experimental Ophthalmology
2013;(3):298-302
- CountryChina
- Language:Chinese
-
Abstract:
Glaucoma is one of the leading causes of blindness worldwide.Its characteristics are chronic neurodegenerative disease of the optic nerve,such as apoptosis of retinal ganglion cells,progressive loss of optic nerve axons and visual fields defects.The elevated intraocular pressure and vascular insufficiency are considered as the major risk factors,and the other factors include the glutamate excitotoxicity,nitric oxide increasing and oxidative stress.In recent years,the immune system changes were found to be participated in the pathogenesis of glaucoma and its damages of optic nerve.The main findings are the autoantibodies of heat shock protein,the elevation of tumor necrosis factor and other proinflammatory cytokines in periphery blood and aqueous humor.The immunological advance of autoantibody,cellular immunity and cytokines in the glaucoma and its neuronal damage were reviewed.
