Changes of serum lipids in patients with Bietti crystalline dystrophy
10.3760/cma.j.issn.2095-0160.2015.01.010
- VernacularTitle:结晶样视网膜色素变性患者血脂浓度的变化
- Author:
Mengda, LI
;
Xiaobei, YIN
;
Ting, HE
;
Xiaowei, SUN
;
Genlin, LI
- Publication Type:Journal Article
- Keywords:
Choroid Diseases/congenital;
Fundus Oculi;
Humans;
Pigment Epithelium of Eye;
Retinal Degeneration/congenital;
Lipids/blood;
Bietti crystalline dystrophy
- From:
Chinese Journal of Experimental Ophthalmology
2015;33(1):47-50
- CountryChina
- Language:Chinese
-
Abstract:
Background Bietti crystalline dystrophy (BCD) is a congenital and autosomal recessive hereditary eye disease characterized by multiple glistening intraretinal crystals scattered over the fundus.Studies determined abnormality of fatty acid metabolism probably is associated with BCD.However,the study on the alteration of blood lipid level in BCD patients is rare.Objective This trail was to study the change of serum lipids in BCD patients.Methods A total of 50 patients with bilateral BCD and 50 matched healthy volunteers were included from November 2011 to March 2013 in Beijing Tongren Eye Center with the approval of Ethic Committee of Beijing Tongren Hospital.Written informed consent was obtained from each subject before any medial examination.Peripheral blood of 3 ml was collected from the subjects.The serum concentrations of triglyceride (TG),total cholesterol (TC),low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were measured and analyzed.The examination outcome was identified based on the criteria of China Adult Dyslipidemia Prevention Guideline (Version 2007).Results Abnormality of serum lipid content was detected in 58.00％ patients (29/50),and hypertriglyceridemia and hypercholesteremia were in 34.48％ (10/29),respectively,and mixed hyperlipidaemia was in 27.59 ％ (8/29).The serum levels of TG,TC and LDL-C were (1.63± 1.19) mmol/L,(5.10±1.05) mmol/L and (3.27±0.97) mmol/L in the BCD group,which were significantly higher than (0.93± 0.33) mmol/L,(4.33 ±0.56) mmol/L,(2.63 ±0.51) mmol/L of the normal group (t =4.036,4.496,4.095,all at P=0.000).Conclusions The serum lipid levels elevate in BCD patients,which might be related to the occurrence of BCD.
