Recent advance research progress on complement factor Ⅰ and age-related macular degeneration
10.3760/cma.j.issn.2095-0160.2015.02.019
- VernacularTitle:补体因子Ⅰ与年龄相关性黄斑变性发生研究进展
- Author:
Qin, WANG
- Publication Type:Journal Article
- Keywords:
Age-related macular degeneration;
Complement system;
Complement factor Ⅰ;
Single-nucleotide polymorphisms
- From:
Chinese Journal of Experimental Ophthalmology
2015;33(2):189-192
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration (AMD) is one of the most important diseases that cause vision loss among older patients in developed countries.As the progress of population aging in China,the incidence of AMD is increasing.The activation of the complement system plays an important role in AMD pathogenesis.Complement factor Ⅰ (CFI) is an important complement regulator.In recent years,there have been numerous studies about CFI single-nucleotide polymorphisms (SNPs) and AMD.The mechanism of CFI and the association between CFI polymorphisms and AMD were reviewed in the article.
