Effect of endogenous electric field on ocular cell behaviors
10.3760/cma.j.issn.2095-0160.2015.06.016
- VernacularTitle:内源性电场对眼内细胞的生物学影响
- Author:
Jun, LIU
- Publication Type:Journal Article
- Keywords:
Electric field;
Cell;
Bioeffects
- From:Chinese Journal of Experimental Ophthalmology
2015;33(6):556-559
- CountryChina
- Language:Chinese
-
Abstract:
Corneal epithelial cells,lens epithelial cells,and retinal pigment epithelium cells contain a vast array of ion channels and pumps.The selective permeability to different ions generates endogenous electric fields and currents in those tissues.Abnormalities in the endogenous electric fields may underlie many ocular diseases,for example chronic corneal ulcers,posterior capsule opacity after cataract surgery,and retinopathies.How the electric fields influence the tissues and cells and participate in the occurrence of the ocular diseases is a hotspot of research in this field.This article briefly reviewed the mechanism of how the endogenous electrical activities are generated,the responses of ocular cells to applied electric fields,potential intracellular signaling mechanisms and clinical implications.Further understanding of this aspect is likely to offer new insights into ocular diseases.
